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Eat your way to a better brain
43. Food for thought
Jul 17th 2008 From The Economist print edition

Eat your way to a better brain (by Barry Downard)

43-1-182

CHILDREN have a lot to contend with these days, not least a tendency for their pushy parents to force-feed them omega-3 oils at every opportunity. These are supposed to make children brainier, so they are being added to everything from bread, milk and pasta to baby formula and vitamin tablets. But omega-3 is just the tip of the nutritional iceberg; many nutrients have proven cognitive effects, and do so throughout a person¡¯s life, not merely when he is a child.
Fernando Gomez-Pinilla, a fish-loving professor of neurosurgery and physiological science at the University of California, Los Angeles, believes that appropriate changes to a person¡¯s diet can enhance his cognitive abilities, protect his brain from damage and counteract the effects of ageing. Dr Gomez-Pinilla has been studying the effects of food on the brain for years, and has now completed a review, just published in Nature Reviews Neuroscience, that has analysed more than 160 studies of food¡¯s effect on the brain. Some foods, he concludes, are like pharmaceutical compounds; their effects are so profound that the mental health of entire countries may be linked to them.
Last year, for example, the Lancet published research showing that folic-acid supplements--sometimes taken by pregnant women--can help those between 50 and 70 years old ward off the cognitive decline that accompanies ageing. In a study lasting three years, Jane Durga, of Wageningen University in the Netherlands, and her colleagues found that people taking such supplements did better on measures of memory, information-processing speed and verbal fluency. That, plus evidence that folate deficiency is associated with clinical depression, suggests eating spinach, orange juice and Marmite, which are all rich in folic acid.

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Another suggestion from Dr Gomez-Pinilla¡¯s review is that people should eat more antioxidants. That idea is not new. Antioxidants are reckoned by many to protect against the general effects of ageing. Vitamin E, for example, which is found in vegetable oils, nuts and green leafy vegetables, has been linked (in mice) with the retention of memory into old age, and also with longer life.
Dr Gomez-Pinilla, however, gives the antioxidant story a particular twist. The brain, he observes, is peculiarly susceptible to oxidative damage. It consumes a lot of energy, and the reactions that release this energy also generate oxidising chemicals. Moreover, brain tissue contains a great deal of oxidisable material, particularly in the fatty membranes surrounding nerve cells.
That suggests, among other things, the value of a diet rich in berries. These have been shown to have strong antioxidant effects, though only a small number of their constituents have been evaluated in detail. One group that has been evaluated, the polyphenols, has been shown in rodents to reduce oxidative damage and to boost the ability to learn and retain memories. In particular, these chemicals affect changes in response to different types of stimulation in the hippocampus (a part of the brain that is crucial to the formation of long-term memories, and which is the region most affected by Alzheimer¡¯s disease). Another polyphenol, curcumin, has also been shown to have protective effects. It reduces memory deficits in animals with brain damage. It may be no coincidence that in India, where a lot of curcumin is consumed (it is the substance that makes turmeric yellow), Alzheimer¡¯s disease is rarer than elsewhere.

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